HAT–HDAC interplay modulates global histone H3K14 acetylation in gene‐coding regions during stress
| Autor: | Yongtao Xue-Franzén, Anthony P. H. Wright, Michelle Rönnerblad, Anna Johnsson, Mickaël Durand-Dubief, Karl Ekwall |
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| Rok vydání: | 2009 |
| Předmět: |
Transcription
Genetic Scientific Report Cell Cycle Proteins Biology SAP30 Biochemistry Histone Deacetylases Histones Open Reading Frames Acetyltransferases Stress Physiological Gene Expression Regulation Fungal Histone H2A Genetics Histone code Molecular Biology Histone Acetyltransferases Histone deacetylase 5 HDAC11 Histone deacetylase 2 Acetylation HDAC4 enzymes and coenzymes (carbohydrates) Schizosaccharomyces pombe Proteins Histone deacetylase Genome Fungal |
| Zdroj: | EMBO reports. 10:1009-1014 |
| ISSN: | 1469-3178 1469-221X |
| DOI: | 10.1038/embor.2009.127 |
| Popis: | Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters. Here, we map genome-wide Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation. An interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes. Our findings suggest a new role for Gcn5 during transcriptional elongation, in addition to its known role in transcriptional initiation. |
| Databáze: | OpenAIRE |
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