Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: the Canadian Asthma Primary Prevention Study
| Autor: | Richard G. Hegele, Katherine Wooldrage, Jure Manfreda, Helen Dimich-Ward, Allan B. Becker, Wade T. A. Watson, Alexander C. Ferguson, Kathy Kyungeun Lee, Moira Chan-Yeung |
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| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Hypersensitivity Immediate Male Allergy Pediatrics medicine.medical_specialty viruses Picornaviridae medicine.disease_cause Atopy Risk Factors medicine Humans Respiratory Tract Infections Asthma business.industry Respiratory disease Age Factors Infant Odds ratio medicine.disease Parainfluenza Virus 1 Human medicine.anatomical_structure Respiratory Syncytial Virus Human Pediatrics Perinatology and Child Health Immunology Female Viral disease Rhinovirus business Respiratory tract |
| Zdroj: | Pediatric pulmonology. 42(3) |
| ISSN: | 8755-6863 |
| Popis: | The contribution of respiratory viral infections to the onset of asthma and atopy is controversial. In "high risk" children (n = 455) born into asthmatic/atopic families, we determined the relationship of exposures to common respiratory viruses and concomitant respiratory symptoms, and to subsequent possible asthma and atopy at ages 1 and 2 years. Frozen nasal specimens, obtained when children were 2 weeks, 4, 8, and 12 months old, underwent reverse transcription-polymerase chain reaction (RT-PCR) testing for parainfluenza virus (PIV), respiratory syncytial virus (RSV), and picornavirus (rhinovirus/enterovirus). Odds ratios of viral RT-PCR results to respiratory symptoms ("cold," rhinitis, cough, wheezing) and to possible asthma or atopy at 1 and 2 years of age were calculated. Positive viral RT-PCR was associated with increased odds of "cold" and cough; PIV and picornavirus were associated with rhinitis, and RSV was associated with wheezing. PIV was associated with increased odds of atopy at 1 year of age in the control group; PIV and RSV were associated with possible asthma at 2 years of age. We conclude that in high-risk children, viral exposures documented by RT-PCR are associated with respiratory symptoms, and exposures to PIV and RSV during the first year of life are associated with the initial onset of possible asthma. |
| Databáze: | OpenAIRE |
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