Synergistic Evaluation of Ginger and Licorice Extracts in a Mouse Model of Colorectal Cancer
| Autor: | Amir Mohammad Saeedifar, Ghasem Mosayebi, Ali Ganji, Ali Ghazavi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Colorectal cancer Medicine (miscellaneous) Apoptosis Ginger Pharmacology Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Glycyrrhiza medicine Animals Humans Cell Proliferation 030109 nutrition & dietetics Nutrition and Dietetics biology Plant Extracts Cell growth Chemistry Soxhlet extractor medicine.disease biology.organism_classification CTL Oncology Cell culture 030220 oncology & carcinogenesis Cancer cell Colorectal Neoplasms |
| Zdroj: | Nutrition and Cancer. 73:1068-1078 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | Herbal medicine can be used to overcome the side effects of conventional treatments. This study aimed to evaluate the anticancer activities of ginger and licorice extracts, as well as the synergistic effects of their combination. Ginger ethanolic extract (GEE) and licorice methanolic extract (LME) were isolated by a Soxhlet extractor. Next, the anti-proliferative activity of the extracts, apoptosis induction, tumor growth inhibition, and tumor-infiltrating T lymphocytes were investigated. The MTT (3-[4, 5-dimethylthiazol-2-yl]-2, five diphenyl tetrazolium bromide) assay showed that GEE and LME decreased the CT26 cell viability in a dose-dependent manner; however, the GEE + LME combination was more effective (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|