Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice
| Autor: | Jieran An, Zhiqian Tong, Hui Yang, Binggui Sun, Xu Yang, Yan Wu, Ge Gao, Wenhong Luo, Rongqiao He, Jianping Jia, Hongjun Luo, Xiangpei Yue, Li Ai, Wenjing Jiang, Shumao Ding, Jihui Lyu, Yufei Mei, Jingnan Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Light Physiology Clinical Biochemistry Formaldehyde medicine.disease_cause Biochemistry Mice 03 medical and health sciences chemistry.chemical_compound Memory medicine Animals Clinical efficacy Red light Hydrogen peroxide Molecular Biology Formaldehyde dehydrogenase General Environmental Science Memory Disorders 030102 biochemistry & molecular biology biology Chemistry Cell Biology Catalase Aldehyde Oxidoreductases Disease Models Animal Oxidative Stress 030104 developmental biology biology.protein General Earth and Planetary Sciences Oxidative stress Acetylcholine medicine.drug |
| Zdroj: | Antioxidants & Redox Signaling. 30:1432-1449 |
| ISSN: | 1557-7716 1523-0864 |
| DOI: | 10.1089/ars.2018.7520 |
| Popis: | Pharmacological treatments for Alzheimer's disease (AD) have not resulted in desirable clinical efficacy over 100 years. Hydrogen peroxide (HWe found that age-associated HWe developed a phototherapeutic device with 630 nm red light, and this LED-RL reduced brain HThe phototherapy of LED-RL has low photo toxicity and high rate of tissue penetration and noninvasively reverses aging-associated cognitive decline. This finding opens a promising opportunity to translate LED-RL into clinical treatment for patients with dementia. Antioxid. Redox Signal. 00, 000-000. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|