The Effect of Body Mass Index on Fasting Blood Glucose and Development of Diabetes Mellitus After Initiation of Extended-Release Niacin
| Autor: | Joy Meier, Julio Lopez, David Siegel, Ardelle Libby, Arthur L.M. Swislocki |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Hospitals Veterans Endocrinology Diabetes and Metabolism medicine.medical_treatment Medication adherence Models Biological Niacin Gastroenterology Body Mass Index Adrenal Cortex Hormones Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Veterans Affairs Aged Retrospective Studies business.industry nutritional and metabolic diseases Retrospective cohort study Middle Aged medicine.disease United States Extended release niacin Endocrinology Diabetes Mellitus Type 2 Delayed-Action Preparations Female business Body mass index |
| Zdroj: | Metabolic Syndrome and Related Disorders. 8:79-84 |
| ISSN: | 1557-8518 1540-4196 |
| Popis: | Niacin increases blood glucose, but whether the degree of increase is associated with increasing body mass index (BMI) is unknown. We evaluated the effect of extended-release niacin initiation on fasting plasma glucose (FPG) and the development of new-onset diabetes mellitus (DM) in relation to body mass index (kg/m(2)) in nondiabetic patients.This retrospective observational study used data from six facilities within a geographical region of the Department of Veterans Affairs (VA). Patients included were 18 years of age or older and on a stable extended-release niacin dose (minimum 100 days) of at least 250 mg/day between January, 2001, and April, 2007. Patients were excluded if they were new to the VA, on corticosteroids or insulin, if medication adherence was80%, or if they met criteria for DM.A total of 811 nondiabetic patients taking extended-release niacin initiation were studied. FPG after niacin initiation was stastically significantly correlated with increasing BMI (P0.001, R = 0.144 Pearson correlation coefficient). Factors independently associated with change in FPG using multiple linear regression were BMI (P = 0.043), baseline average glucose (P0.001), and baseline average triglycerides (P = 0.037). Of all patients started on niacin, 220 (27.1%) patients developed DM after niacin initiation. BMI, (P = 0.002) and baseline average glucose (P0.001) were independent predictors of the development of new-onset DM (logistic regression analysis).We found an association between increasing BMI and increasing FPG and diagnosis of new-onset DM after initiation of extended-release niacin initiation. This suggests that extended-release niacin may increase FPG into the diabetic range, especially for obese patients. |
| Databáze: | OpenAIRE |
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