The effect of (-)-linalool on the metabolic activity of liver CYP enzymes in rats
| Autor: | Roman Řemínek, Kristýna Nosková, Jan Juřica, Ondřej Zendulka, Gabriela Přibyl Dovrtělová |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Insecticides Physiology Acyclic Monoterpenes Lavender oil Pharmacology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Non-competitive inhibition Diclofenac Linalool Cytochrome P-450 Enzyme System medicine Animals Rats Wistar Testosterone biology Dose-Response Relationship Drug Chemistry General Medicine biology.organism_classification 3. Good health Rats Dose–response relationship Liver Microsome Microsomes Liver Monoterpenes Lamiaceae 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1802-9973 |
| Popis: | (-)-Linalool is the major floral scent occurring mainly in families Lamiaceae, Lauraceae and Rutaceae and is the main active compound of lavender oil. The purpose of this study was to reveal the influence of subchronic systemic treatment with (-)-linalool on the metabolic activity of CYP2A, 2B, 2C6, 2C11 and 3A in rat liver microsomes (RLM). The second aim was to reveal possible inhibitory effect of (-)-linalool on CYP2C6 in vitro. Wistar albino male rats were treated with (-)-linalool intragastrically at the doses of 40, 120, and 360 mg/kg/day for 13 days. Treatment with (-)-linalool at the dose of 360 mg/kg increased the metabolic activity of CYP2A assessed with testosterone as a probe substrate. (-)-Linalool showed weak competitive inhibition of CYP2C6 in rat liver microsomes, with IC50 of 84 μM with use of diclofenac as a probe substrate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|