Significance of RANTES‐CCR5 axis and linked downstream immunomodulation in Dengue pathogenesis: A study from Guwahati, India
| Autor: | Sujoy Bose, Anjan Kumar Saikia, Trishna Kalita, Raktim Borkotoky, Mafidul Islam, Nidhi Singh, Anjuma Begum, Vargab Baruah |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Receptors CCR5 medicine.medical_treatment Population India Viremia Dengue virus Lymphocyte Activation medicine.disease_cause Monocytes Dengue fever Dengue Immunomodulation Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Virology medicine Humans Prospective Studies Severe Dengue 030212 general & internal medicine education Chemokine CCL5 education.field_of_study Tumor Necrosis Factor-alpha business.industry Middle Aged Th1 Cells medicine.disease Interleukin-10 Interleukin 10 Infectious Diseases Cytokine Cytokines Female 030211 gastroenterology & hepatology Tumor necrosis factor alpha business |
| Zdroj: | Journal of Medical Virology. 91:2066-2073 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | We aimed to evaluate the significance of the RANTES-CCR5 axis and resulting immunomodulatory status in Dengue pathogenesis involving a Guwahati, India based population where Dengue cases have increased alarmingly. An increased CC-chemokine receptor type 5 (CCR5) messenger RNA expression and CCR5 positive cell count profile was observed in Dengue cases, the highest being in severe cases. CCR5 ligand RANTES expression was significantly decreased in Dengue cases and inversely correlated with Dengue viremia fold change in severe cases. Monocytes are involved in Dengue virus homing and replication. Its levels and activation profile were higher in Dengue cases. A hyper Th1-biased immunomodulatory profile with upregulated tumor necrosis factor-α levels, and downregulated expression of antiviral cytokine interferon-γ and key regulatory Th2 anti-inflammatory cytokine interleukin 10 was observed in severe Dengue cases compared with mild Dengue cases and controls. The results, therefore, suggest the significance of RANTES-CCR5 axis deregulation and resulting altered immunomodulation in Dengue pathogenesis, and holds prognostic and therapeutic significance. |
| Databáze: | OpenAIRE |
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