Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site

Autor:	Ying Zhu, Xiaojing Gong, Zonghai Sheng, Jingqin Chen, Peng Zhang, Chengbo Liu, Huixiang Yan, Hairong Zheng, Rongqin Zheng, Dong Chen, Liang Song, Ningbo Chen
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Brain glioma Materials science Biocompatibility genetic structures Photoacoustic imaging in biomedicine Molecular imaging 02 engineering and technology 010402 general chemistry 01 natural sciences lcsh:Technology chemistry.chemical_compound In vivo Glioma medicine Electrical and Electronic Engineering Orthotopic brain glioma MoS2–ICG hybrid lcsh:T Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease eye diseases 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Photoacoustic imaging 0210 nano-technology Indocyanine green Biomedical engineering
Zdroj:	Nano-Micro Letters, Vol 10, Iss 3, Pp 1-12 (2018)
ISSN:	2150-5551 2311-6706
DOI:	10.1007/s40820-018-0202-8
Popis:	Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975343a9e9e78b9fc10ed81eeec92457 http://link.springer.com/article/10.1007/s40820-018-0202-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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