Instrumental Activities of Daily Living, Neuropsychiatric Symptoms, and Neuropsychological Impairment in Mild Cognitive Impairment
| Autor: | Stephanie Higgins, Anita Chopra, Terrie Ginsberg, David J. Libon, Leonard Powell, Victor Wasserman, Thomas A. Cavalieri, Sheina Emrani |
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| Rok vydání: | 2019 |
| Předmět: |
Complementary and Manual Therapy
Activities of daily living Memory Episodic Apathy Neuropsychological Tests 050105 experimental psychology Executive Function 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Activities of Daily Living medicine Humans Dementia Cognitive Dysfunction 0501 psychology and cognitive sciences Cognitive decline Episodic memory Aged Aged 80 and over Depression business.industry 05 social sciences Memory clinic Neuropsychology medicine.disease Complementary and alternative medicine medicine.symptom business 030217 neurology & neurosurgery Geriatric psychiatry Clinical psychology |
| Zdroj: | Journal of Osteopathic Medicine. 119:96-101 |
| ISSN: | 2702-3648 |
| DOI: | 10.7556/jaoa.2019.015 |
| Popis: | Background Neuropsychological deficits, neuropsychiatric symptoms, and problems with instrumental activities of daily living are common in participants with mild cognitive impairment (MCI). Objectives To assess how subtle to mildly impaired instrumental activities of daily living (IADLs) might be related to neuropsychological abilities (including executive control and episodic memory) and neuropsychiatric symptoms (including apathy and depression) among participants with a diagnosis of MCI. Methods Participants were evaluated for MCI and possible dementia at an outpatient memory clinic on the basis of a comprehensive neuropsychological evaluation, a geriatric psychiatry evaluation, a magnetic resonance image of the brain, and serum studies to evaluate for a possible reversible cause of cognitive decline. A series of stepwise regression analyses were conducted whereby IADL ability was the dependent variable and neuropsychological abilities, such as executive control and episodic memory, or neuropsychiatric symptoms, including apathy and depression, were the independent or predictor variables. The presence and severity of neuropsychiatric symptoms was assessed using a modified version of the Neuropsychiatric Inventory (mNPI). Participants were grouped by MCI diagnosis status (amnestic MCI, combined dysexecutive/mixed MCI, and no MCI). Results Twenty-six participants were in the amnestic MCI group, 19 in the combined dysexecutive/mixed MCI group, and 36 participants did not meet criteria for MCI (non-MCI group). Groups did not differ in age, education, Mini-Mental State Examination performance, IADL abilities, estimated premorbid general intellectual abilities, or mNPI ratings for apathy and depression. Stepwise regression analyses found a robust relationship between mild IADL impairment and greater apathy (R=0.497, r 2 1,69=0.247, PPR=0.271, r 2 1,68=0.073, PPR=0.497, R 2 1,69=0.247, PP Conclusion Mildly impaired IADL functioning can negatively affect quality of life. Moreover, apathy may be amenable to treatment. In a primary geriatric care setting, neuropsychiatric symptoms and neuropsychological abilities should be routinely assessed. |
| Databáze: | OpenAIRE |
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