Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome
| Autor: | Nariman F. Salakhutdinov, Sergey Kuranov, Olga A. Luzina, V. V. Fomenko, Marina S. Borisova, Tatyana G. Tolstikova, M. V. Khvostov, D. S. Baev, Mikhail Blokhin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
natural product
type 2 diabetes mellitus glucose tolerance Pharmaceutical Science lcsh:RS1-441 Pharmacology lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Total cholesterol medicine triterpenic amides 030304 developmental biology Glycemic 0303 health sciences Natural product total cholesterol medicine.disease chemistry 030220 oncology & carcinogenesis hypoglycemic activity lipids (amino acids peptides and proteins) Animal studies Metabolic syndrome Pharmacophore Derivative (chemistry) |
| Zdroj: | Scientia Pharmaceutica, Vol 89, Iss 4, p 4 (2021) Scientia Pharmaceutica Volume 89 Issue 1 |
| ISSN: | 0036-8709 2218-0532 |
| Popis: | A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57BL/6 mice placed on a high-fat/high-cholesterol diet. Of all tested compounds, the dihydrobetulonic derivative (16b) had the most pronounced effect in decreasing blood glucose levels, total cholesterol (TC), and high-density lipoproteins (HDL). All the synthesized compounds displayed a relatively safe profile in the animal studies carried out in this work. |
| Databáze: | OpenAIRE |
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