Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter?
| Autor: | Helena Parfenova, Jianxiong Liu, Alex Fedinec, Charles W. Leffler, Massroor Pourcyrous |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Time Factors Endothelium Vasodilator Agents Sus scrofa Carbonates Physiology Vasodilation Bicuculline Article Antioxidants 03 medical and health sciences Sex Factors 0302 clinical medicine Seizures Sex factors medicine Neonatal brain Animals Humans Boranes business.industry Endothelial Cells Cerebral Arteries 3. Good health Cerebrovascular Disorders Disease Models Animal 030104 developmental biology medicine.anatomical_structure Animals Newborn Astrocytes Pediatrics Perinatology and Child Health Pia Mater Female business 030217 neurology & neurosurgery Cranial window Astrocyte medicine.drug |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/pr.2017.152 |
| Popis: | BACKGROUND The potential contribution of sex-related variables to cerebrovascular functions in neonates remains elusive. Newborn piglets provide a translationally relevant model for studying the effects of seizures in the neonatal brain. The present study investigated whether sex differences contribute to cerebrovascular functions in healthy and epileptic newborn pigs. METHODS Epileptic seizures were induced in female and male newborn pigs by bicuculline. An antioxidant drug, the carbon monoxide-releasing molecule CORM-A1, was administered enterally before or during seizures. The responses of pial arterioles to endothelium-, astrocyte-, and vascular smooth muscle-dependent vasodilators were tested in intact and 48-h postictal piglets using the cranial window technique. RESULTS In intact newborn pigs, we did not observe any sex-related differences in cerebrovascular functions. In the postictal male and female newborn pigs, a dramatic reduction in responses of pial arterioles to endothelium- and astrocyte-dependent vasodilators was detected. CORM-A1, administered before or during seizures, greatly improved the outcome of seizures on cerebrovascular functions in both male and female piglets. CONCLUSION We found no evidence of sex-related differences in cerebral vasodilator functions in control and epileptic newborn pigs. In both male and female newborns, epileptic seizures lead to prolonged cerebral vascular dysfunction that is effectively prevented by CORM-A1 therapy. |
| Databáze: | OpenAIRE |
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