Absorption of L-lysine diatrizoate from the gastrointestinal tract: the effect of surgery, inflammation, and neoplasia
| Autor: | Gerhard Dietz, Peter Weinberg, W. Golder, Michael Jarosch, Klaus Rittinghaus |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Oral Contrast Media Diatrizoate Gastroenterology Intestinal absorption Sex Factors Oral administration Administration Rectal Internal medicine Abdomen Intestinal Neoplasms medicine Humans Prospective Studies Diatrizoic Acid Chromatography High Pressure Liquid Aged Aged 80 and over Inflammation Gastrointestinal tract business.industry Lysine Age Factors Middle Aged Surgery Radiography Contrast medium medicine.anatomical_structure Intestinal Absorption Rectal administration Data Interpretation Statistical Female business Digestive System medicine.drug |
| Zdroj: | International journal of colorectal disease. 18(5) |
| ISSN: | 0179-1958 |
| Popis: | To ascertain whether the absorption of L-lysine diatrizoate, a sodium-free salt of the contrast-giving diatrizoic acid from the gastrointestinal tract is increased by surgery, inflammation, and neoplasia.The prospective study comprised 32 patients who were undergoing radiological examination of the upper gastrointestinal tract with a contrast medium containing L-lysine diatrizoate and 52 further patients who were undergoing examination of the lower gastrointestinal tract in the same way. The concentration of diatrizoic acid was determined by high-pressure liquid chromatography in blood samples taken before and immediately after the radiological examinations. The results were examined in terms of sex, age, surgical history, and any evidence of inflammatory or neoplastic diseases.The serum diatrizoic acid concentration in patients tested after oral administration was 3.62 microg/ml. In patients who had undergone operation the titer was lower than in those who had not been operated on. Serum diatrizoic acid concentration in patients tested after rectal administration was 0.30 microg/ml. In patients suffering from inflammatory conditions or neoplasms the titer was significantly higher than in the other patients.The L-lysine salt of diatrizoic acid is absorbed in larger amounts from the upper gastrointestinal tract than from the lower. Absorption is not increased after surgical operations on the viscera. However, inflammatory conditions and neoplasms involving the large bowel increase the uptake of the contrast medium from the intestine. |
| Databáze: | OpenAIRE |
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