Correlation Between Different Interbody Grafts and Pseudarthrosis After Anterior Cervical Discectomy and Fusion Compared with Control Group: Systematic Review
| Autor: | Sergio Cavalheiro, Enrico Affonso Barletta, Telmo Augusto Barba Belsuzarri, Andrei Fernandes Joaquim, Franz Jooji Onishi, Eduardo Augusto Iunes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Polymers Bone Morphogenetic Protein 2 Anterior cervical discectomy and fusion Prosthesis Design Bone morphogenetic protein Transplantation Autologous Spinal Cord Diseases Polyethylene Glycols Prosthesis Implantation Benzophenones 03 medical and health sciences Myelopathy Postoperative Complications 0302 clinical medicine Risk Factors Transforming Growth Factor beta Odds Ratio medicine Humans Polymethyl Methacrylate Risk factor Titanium Bone Transplantation business.industry Significant difference Odds ratio Ketones medicine.disease Cervical spine Carbon Recombinant Proteins Surgery Pseudarthrosis Spinal Fusion 030220 oncology & carcinogenesis Cervical Vertebrae Spinal Diseases Neurology (clinical) business 030217 neurology & neurosurgery Diskectomy |
| Zdroj: | World Neurosurgery. 134:272-279 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.10.100 |
| Popis: | Background Cervical spine degenerative disease is one of the main causes of myelopathy. Anterior cervical discectomy and fusion (ACDF) is the most common surgical procedure used to treat cervical myelopathy. Therefore, it is important to study pseudarthrosis rates after ACDF and correlate them with the graft used. Methods We performed a systematic review to evaluate the relationship between pseudarthrosis after ACDF and the interbody graft used. Results A total of 3732 patients were evaluated in 46 studies. The mean age of the included patients was 51.5 ± 4.18 years (range, 42–59.6 years). ACDF is most often perforemd as single-level surgery and the level most impaired is C5-C6. The use of titanium cages, zero profile, recombinant human bone morphogenetic protein 2, and carbon cages was seen as a protective factor for pseudarthrosis compared with the autograft group (control group); with an odds ratio of 0.29, 0.51, 0.03, and 0.3, respectively; the results were statistically relevant. The use of polyetheretherketone, poly(methyl methacrylate), and trabecular metal was a risk factor for development of pseudarthrosis compared with the control group, with an odds ratio of 1.7, 8.7, and 6.8, respectively; the results were statistically relevant. Radiologic follow-up was an important factor for the pseudarthrosis rate; paradoxically, a short follow-up ( 2 years increased the chance of finding pseudarthrosis. Conclusions Different types of grafts lead to a significant difference in pseudarthrosis rates. Follow-up time is also an important factor that affects the rate of pseudarthrosis after ACDF. |
| Databáze: | OpenAIRE |
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