One-pot organocatalytic/multicomponent approach for the preparation of novel enantioenriched non-natural selenium-based peptoids and peptide-peptoid conjugates

Autor:	Márcio W. Paixão, Antonio L. Braga, Alexander F. de la Torre, Fábio Z. Galetto, Akbar Ali, José A C Delgado
Rok vydání:	2018
Předmět:	Magnetic Resonance Spectroscopy chemistry.chemical_element Peptide Chemistry Techniques Synthetic 010402 general chemistry 01 natural sciences Aldehyde Catalysis Inorganic Chemistry chemistry.chemical_compound Peptoids Selenium Drug Discovery Moiety Physical and Theoretical Chemistry Molecular Biology chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Peptoid General Medicine Combinatorial chemistry 0104 chemical sciences Organic Chemistry Phenomena chemistry Organocatalysis Ugi reaction Stereoselectivity Information Systems
Zdroj:	Molecular diversity. 24(1)
ISSN:	1573-501X
Popis:	A combined organocatalytic and multicomponent synthetic approach was designed for the preparation of selenium-based peptoids and peptide-peptoid conjugates. This single-step synthetic protocol comprises the organocatalytic asymmetric insertion of phenylselenium in the aldehyde moiety followed by the Ugi four-component reaction which results in obtaining the desired compounds in good-to-moderate yields and with good-to-excellent levels of stereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9748e7379efd48d89e7393541af2e409 https://pubmed.ncbi.nlm.nih.gov/30778816 Zobrazit plný text záznamu Full text from SpringerLink