Efficacy of spinal cord stimulation as adjuvant therapy for intractable angina pectoris: A prospective, randomized clinical study
| Autor: | M. J. L. De Jongste, Raymond W.M. Hautvast, Kong I. Lie, Hans L. Hillege |
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| Rok vydání: | 1994 |
| Předmět: |
VASODILATATION
Randomization business.industry PAIN ELECTRICAL-STIMULATION Spinal cord medicine.disease law.invention MECHANISMS Clinical trial Angina medicine.anatomical_structure TRIALS Randomized controlled trial Quality of life law Anesthesia medicine Adjuvant therapy Prospective cohort study business PHYSIOLOGY Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology, 23(7), 1592-1597. ELSEVIER SCIENCE INC |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/0735-1097(94)90661-0 |
| Popis: | Objectives. In a prospective, randomized study with an 8-week follow-up period, we evaluated the efficacy of spinal cord stimulation an exercise capacity and quality of life in patients with intractable angina.Background. Despite important achievements in therapy for ischemic heart disease, there remain patients with intractable symptoms of angina. In uncontrolled observations, several investigators have reported beneficial effects of spinal cord stimulation as an additional therapy for patients with angina pectoris.Methods. Seventeen patients were randomly assigned to the treatment (implantation within 2 weeks, eight patients) or control (implantation after 8 weeks, nine patients) group. Assessment of exercise capacity was performed by treadmill exercise testing. Quality of life was evaluated by daily and social activity scores and recording sublingual glyceryl trinitrate intake and angina pectoris attacks in a diary. After the 8-week study period, the control group also received the spinal cord stimulation device, and all patients were followed up for 12 months.Results. The treatment but not the control group demonstrated a significant increase in exercise duration (p Conclusions. Spinal cord stimulation significantly improves exercise capacity and quality of life. On the basis of an increase in exercise capacity and rate pressure product, the mechanism by which spinal cord stimulation acts may be related to improved oxygen supply to the heart combined with an analgesic effect. |
| Databáze: | OpenAIRE |
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