Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study
| Autor: | M. Ensari Guneli, Şule Özbilgin, Ali Günerli, Derya Aslan Yurtlu, Bülent Serhan Yurtlu, Sezen Korkut, Volkan Hanci, Beyza Kucukoztas, Gonca Kamacı |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Digoxin
Time Factors Antidotes 030204 cardiovascular system & hematology Toxicology Sugammadex 03 medical and health sciences 0302 clinical medicine Bolus (medicine) Heart Rate Heart rate polycyclic compounds Medicine Animals Asystole Rats Wistar Infusions Intravenous Molecular Biology Cardiotoxicity business.industry digestive oral and skin physiology Lethal dose 030208 emergency & critical care medicine medicine.disease Myocardial Contraction Heart Arrest carbohydrates (lipids) Anesthesia Toxicity Injections Intravenous Cardiology and Cardiovascular Medicine business medicine.drug |
| Popis: | Previous studies have shown that cyclodextrin group medicines bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to digoxin and delay the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with digoxin at 3 mg/h (0.25 mg/ml). Five minutes after the start of infusion, animals were treated with a bolus of either 16 mg/kg (Sgdx16), 100 mg/kg (Sgdx100), or 1000 mg/kg (Sgdx1000) sugammadex. The control group infusion did not contain sugammadex. Heart rate, electrocardiography, and respiratory rate were monitored. The primary endpoint was time to asystole. Digoxin infusion continued until the animals arrested. The time to asystole for the Sgdx1000 group was significantly longer compared to that for the control group (p |
| Databáze: | OpenAIRE |
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