The relation of hippocampal subfield volumes to verbal episodic memory measured by the California Verbal Learning Test II in healthy adults

Autor: Per M. Aslaksen, Torgil Riise Vangberg, Marte Ørbo, Martin Bystad
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Memory
Episodic
FreeSurfer
Verbal memory
Neuropsychological Tests
Audiology
Hippocampal formation
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752
Hippocampus
Functional Laterality
050105 experimental psychology
California Verbal Learning Test
Young Adult
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
medicine
Humans
0501 psychology and cognitive sciences
Cognitive skill
Healthy volunteers
Association (psychology)
Episodic memory
Aged
05 social sciences
Wechsler Adult Intelligence Scale
Recognition
Psychology
Organ Size
Middle Aged
Hippocampal subfields
Magnetic Resonance Imaging
Cognitive test
Pattern Recognition
Physiological
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752
Mental Recall
Speech Perception
Female
Psychology
030217 neurology & neurosurgery
Zdroj: Behavioural Brain Research. 351:131-137
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2018.06.008
Popis: Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separate hippocampal subfields and verbal episodic memory performance in healthy volunteers. Forty-seven participants (31 females) between 20–71 years age underwent testing with the California Verbal Learning Test II (CVLT II), and the Wechsler Abbreviated Scale of Intelligence (WASI) to obtain an estimate of cognitive functioning. T1-weighted MR images were obtained after cognitive testing, and volumetric estimates adjusted for age and estimated total intracranial volume were calculated in the FreeSurfer 6.0 software suite for cerebral -and hippocampal structures. The sample performed within the statistical normal range on both CVLT II and WASI. Significant correlations adjusted for multiple testing were found between CVLT II subtests of total learning, free immediate recall and free delayed recall and volumes of the left Cornu Ammonis (CA) 1–4 subfields. There were no significant correlations between right hippocampal subfields and CVLT II performance, and no significant correlation between WASI results and hippocampal subfields. The present results suggest that better verbal episodic memory measured by the CVLT II is associated with relative larger volumes of specific left CA hippocampal subfields in healthy adults. Due to the small sample size and large age-span of the participants, the present findings are preliminary and should be confirmed in larger samples.
Databáze: OpenAIRE
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