Nanomaterial Lipid-Based Carrier for Non-Invasive Capsaicin Delivery; Manufacturing Scale-Up and Human Irritation Assessment
| Autor: | Songyot Anuchapreeda, Narinthorn Buranapreecha, Napatra Tovanabutra, Wajee Wattanasri, Suree Lekawanvijit, Ornchuma Naksuriya, Chadarat Ampasavate, Songwut Yotsawimonwat, Phunsuk Anantaworasakul, Pimporn Anantaworasakul |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pharmaceutical Science Human skin 02 engineering and technology medicine.disease_cause Administration Cutaneous 030226 pharmacology & pharmacy capsaicin human skin irritation Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Young Adult chili extract 0302 clinical medicine Drug Delivery Systems Dermis lcsh:Organic chemistry Drug Discovery medicine Humans Physical and Theoretical Chemistry Transdermal Skin Chromatography Organic Chemistry Non invasive food and beverages Permeation Middle Aged 021001 nanoscience & nanotechnology Skin Irritancy Tests topical delivery system Nanostructures medicine.anatomical_structure Skin irritation chemistry Chemistry (miscellaneous) Capsaicin Delayed-Action Preparations Molecular Medicine NLC Female Irritation 0210 nano-technology Capsicum |
| Zdroj: | Molecules, Vol 25, Iss 5575, p 5575 (2020) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Capsaicin is an active compound in chili peppers (Capsicum chinense) that has been approved for chronic pain treatment. The topical application of high-strength capsaicin has been proven to reduce pain; however, skin irritation is a major drawback. The aim of this study was to investigate an appropriate and scalable technique for preparing nanostructured lipid carriers (NLCs) containing 0.25% capsaicin from capsicum oleoresin (NLC_C) and to evaluate the irritation of human skin by chili-extract-loaded NLCs incorporated in a gel formulation (Gel NLC_C). High-shear homogenization with high intensity (10,000 rpm) was selected to create uniform nanoparticles with a size range from 106 to 156 nm. Both the NLC_C and Gel NLC_C formulations expressed greater physical and chemical stabilities than the free chili formulation. Release and porcine biopsy studies revealed the sustained drug release and significant permeation of the NLCs through the outer skin layer, distributing in the dermis better than the free compounds. Finally, the alleviation of irritation and the decrease in uncomfortable feelings following the application of the Gel NLC_C formulation were compared to the effects from a chili gel and a commercial product in thirty healthy volunteers. The chili-extract-loaded NLCs were shown to be applicable for the transdermal delivery of capsaicin whilst minimizing skin irritation, the major noncompliance cause of patients. |
| Databáze: | OpenAIRE |
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