Induction of immune responses and allergic reactions in piglets by injecting glycinin
Autor: | Cheng Ming Cao, Jin Jie Wu, Xi Chun Wang, Shu Liang Xu, Yu Li, Ting Ting Meng, Shi Bin Feng, Yu Zhang |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
medicine.medical_specialty animal diseases Glycinin Ileum mucosa histology Immunoglobulin E 03 medical and health sciences chemistry.chemical_compound Immune system Antigen Internal medicine medicine Weaning lcsh:SF1-1100 biology 0402 animal and dairy science 04 agricultural and veterinary sciences histamine 040201 dairy & animal science 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Immunology biology.protein Duodenum piglet Animal Science and Zoology lcsh:Animal culture Antibody immunoglobulin Histamine |
Zdroj: | Italian Journal of Animal Science, Vol 15, Iss 1, Pp 166-173 (2016) |
ISSN: | 1828-051X |
Popis: | Glycinin, an antigenic glycoprotein found in soybeans, is the major cause of allergic reactions in young animals. The objective of this study was to evaluate the effects of a prior immunisation of sucking piglets with glycinin on their post-weaning growth performance, serum immunoglobulin contents, small intestinal histamine release and mucosal histology. Forty piglets (7 d of age) were randomly divided into four groups of 10 piglets each. Piglets of Group C (Control) received a physiological saline solution, Groups Im (Immunised) and Im + S (Sensitised) were immunised twice with 500 μg/kg of glycinin at 7 and 21-d-old. All piglets were weaned at 23 d; Groups Im + S and S were sensitised with 2500 μg/kg of glycinin at weaning. Compared with Group C, in Group S the average daily gain (ADG), average daily feed intake and gain:feed ratio were decreased, and serum levels of IgG and IgE were increased. Furthermore, in this group, the histamine levels in the duodenum and ileum were significantly decreased, and the structure of duodenal and ileal mucosa was severely damaged. On the contrary, in Groups Im and Im + S the ADG was increased, serum IgE levels were decreased, intestinal histamine levels were increased and the intestinal mucosa was not damaged. These findings suggest that prior immunisation with glycinin can protect the structural integrity of the intestinal mucosal epithelia and alleviate allergic reactions in piglets. |
Databáze: | OpenAIRE |
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