PHOTODYNAMIC THERAPY OF TYPICAL AND ATYPICAL KERATOACANTHOMA
| Autor: | Y. V. Molochkova, Kuntsevich, Zh S., Sukhova, T. E., Dibirova, S. D., Galkin, V. N., Ivanov, S. A., Romanko, Yu S. |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030103 biophysics medicine.medical_specialty photosensitizer business.industry squamous cell skin cancer laser irradiation Light guide General Medicine Squamous cell skin cancer skin tumors typical keratoacanthoma Atrophic scarring Dermatology Surgery atypical keratoacanthoma 03 medical and health sciences photodynamic therapy Medicine Radachlorin business Normal skin |
| Zdroj: | BASE-Bielefeld Academic Search Engine Alʹmanah Kliničeskoj Mediciny, Vol 44, Iss 1, Pp 64-70 (2016) |
| ISSN: | 2072-0505 |
| DOI: | 10.18786/2072-0505-2016-44-1-64-70 |
| Popis: | Background: Photodynamic therapy (PDT) has shown its clinical efcacy in the treatment of keratoacanthoma. However, the published data is scarce and contradictory. Methods of a photosensitizer administration and irradiation doses depending on the type of keratoacanthoma have not been defned. Aim: To develop the diferentiated approached to PDT for typical and atypical keratoacanthoma by variation of the light density while using of a chlorine photosensitizer. Materials and methods: We assessed and treated 36 patients with cytologically and/or histologically confrmed solitary keratoacanthomas, among them 22 patients with typical and 14 patients with atypical ones. In 12 patients, persistent keratoacanthomas were diagnosed, in 1, a gigantic one and in 1, a centripetal one. Each patient was administered one session of PDT with an intralesional administration of a photosensitizer Radachlorin at a dose of 0.75 mL/cm3. The source of laser irradiation was a medical laser device LAMI (with the wave- length of 662 ± 3 nm, the power of irradiation at the edge of the light guide, 2 Wt). The absorbed light density was 50 J/cm2 for typical keratoacanthomas and 300 J/cm2 for atypical ones. 70 Results: After the treatment, in 32 (89%) of patients the tumor completely regressed within one month (26 ± 1.3 days). In 4 patients (all with atypical keratoacanthomas) the tumors did not regress within one month and was removed surgically with the 3 mm margins of obviously normal skin. At the site of former tumors, there were areas of atrophic scarring (26 cases, in 4 patients, with hyperpigmentation) or with normotrophic scarring (10 patients) that were cosmetically acceptable. Within the next 2 years of the follow-up no relapses were observed. Conclusion: Thus, we proposed an efective method of diferentiated approach to PDT of typical and atypical keratoacanthomas based on one PDT session with an intralesional administration of Radachlorin at a dose of 0.75 mg/cm3 of the tumor, with the intensity of irradiation of 0.39 Wt/cm2. The light dose density for typical keratoacanthomas is 50 J/cm2 and for atypical ones, 300 J/cm2. |
| Databáze: | OpenAIRE |
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