Increased Levels of Tumor Necrosis Alpha and Soluble Vascular Endothel Adhesion Molecule-1 in the Cerebrospinal Fluid of Patients with Connective Tissue Diseases and Multiple Sclerosis
| Autor: | Krisztina Baraczka, Ildikó Szüts, K. Nékám, G. Ormos, Teréz Pozsonyi |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Multiple Sclerosis Central nervous system Vascular Cell Adhesion Molecule-1 Alpha (ethology) Connective tissue Adhesion (medicine) Cerebrospinal fluid Central Nervous System Diseases medicine Humans Connective Tissue Diseases Cell adhesion Autoantibodies General Immunology and Microbiology Tumor Necrosis Factor-alpha business.industry Multiple sclerosis General Medicine Middle Aged medicine.disease medicine.anatomical_structure Solubility Case-Control Studies Female Tumor necrosis factor alpha business |
| Zdroj: | Acta Microbiologica et Immunologica Hungarica. 50:339-348 |
| ISSN: | 1588-2640 1217-8950 |
| DOI: | 10.1556/amicr.50.2003.4.3 |
| Popis: | The aim of the present study was to investigate the serum and cerebrospinal fluid (CSF) concentrations of tumor necrosis factor alpha (TNF-alpha) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with primary progressive form of multiple sclerosis (MS) and in patients with connective tissue diseases (CTDs) complicated with central nervous system (CNS) involvement. Stimulation of sVCAM-1 release by TNF-alpha was demonstrated on endothelial cells of brain vessels. We intended to present the TNF-alpha stimulated elevation of sVCAM-1 in the serum and CSF in any cases of CNS lesion. Fifty patients with several CTDs complicated with neuropsychiatric symptoms and 25 MS patients with primary chronic progressive form of the disease were selected. Determinations of TNF-alpha and sVCAM-1 were performed using ELISA methods. TNF-alpha and sVCAM-1 concentrations were elevated in the CSF of all patients, intrathecal synthesis of sVCAM-1 was demonstrated in MS patients. The changes in the TNF-alpha and sVCAM-1 concentrations were independent from the clinical manifestations, immunoserological changes and quality of neuropsychiatric symptoms of the CTDs. The stimulatory effect of TNF-alpha was more pronounced in the CSF of MS patients. |
| Databáze: | OpenAIRE |
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