Human calcitonin has the same inhibitory effect on osteoclastic bone resorption by human giant cell tumor cells as salmon calcitonin
| Autor: | Magota K, Takahide Kurokawa, Hiroshi Mano, S. Iida, Kitajima Y, Hirohiko Azuma, Mori Y, Nakamura N, M. Matsui, Yoshiyuki Hakeda, Shinji Kakudo, Masayoshi Kumegawa |
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| Rok vydání: | 1996 |
| Předmět: |
Calcitonin
musculoskeletal diseases medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoclasts Bone Neoplasms Cell Fractionation Giant Cells Bone resorption Mice Endocrinology Species Specificity immune system diseases hemic and lymphatic diseases Internal medicine Tumor Cells Cultured medicine Animals Humans Orthopedics and Sports Medicine Salmon calcitonin Bone Resorption Receptor Inhibitory effect Chemistry medicine.disease Resorption Microscopy Electron surgical procedures operative Giant cell Rabbits Human calcitonin Giant-cell tumor of bone |
| Zdroj: | Calcified Tissue International. 59:100-104 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/s002239900094 |
| Popis: | Human calcitonin (hCT) has been reported to have a less hypocalcemizing effect on rats and to have a lower binding affinity for the receptor of mouse osteoclasts than salmon CT(sCT). In this study we comparatively examined the effect of hCT and sCT on osteoclastic bone-resorbing activity of unfractionated cells obtained from human giant cell tumor of bone and from rabbit and mouse long bones. We found that hCT had the same inhibitory effect as sCT on the bone-resorbing activity of human and rabbit osteoclastic cells, but a different one on that of mouse cells. These results indicate that the activity of drugs should be assayed using human cells if possible. |
| Databáze: | OpenAIRE |
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