Effects of acute cold exposure on blood–brain barrier permeability in acute and chronic hyperglycemic rats
| Autor: | Nadir Arican, İmdat Elmas, Vedat Cimen, Mehmet Kaya, Rivaze Kalayci, Mutlu Küçük |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Cerebellum Central nervous system Blood Pressure Blood–brain barrier Permeability Pathology and Forensic Medicine chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Coloring Agents Evans Blue business.industry Body Weight Albumin Pathophysiology Extravasation Rats Cold Temperature medicine.anatomical_structure Blood pressure Endocrinology chemistry Blood-Brain Barrier Hyperglycemia Anesthesia Acute Disease Chronic Disease business Law Extravasation of Diagnostic and Therapeutic Materials |
| Zdroj: | Forensic Science International. 125:137-141 |
| ISSN: | 0379-0738 |
| DOI: | 10.1016/s0379-0738(01)00629-6 |
| Popis: | These experiments were carried out to study, the effects of cold exposure on the permeability of blood-brain barrier (BBB) in hyperglycemic rats. The integrity of the BBB was investigated using Evans blue albumin (EBA) extravasation. Serum glucose levels in hyperglycemic rats were significantly higher than that obtained from normoglycemic rats (P < 0.05). Mean arterial blood pressure in hypothermic groups significantly dropped into lower levels, than that obtained in normothermic groups (P < 0.05). The EBA extravasation to the cerebellum in the group of cold exposure+acute hyperglycemia significantly increased compared with the values obtained from the cold exposure group (P < 0.05). The EBA extravasation to the brain regions of diabetic rats exposed to cold increased more than that in normotermic control rats (P < 0.05), but did not exceed the levels in cold controls. The result of this study suggests that, acute hyperglycemia superimposed upon the permeability of BBB in the rat exposed to cold, only in selected regions of the brain, especially the cerebellum, and this result could be an important factor to explain the mechanisms of death related with hyperglycemia+cold exposure in forensic medicine. |
| Databáze: | OpenAIRE |
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