The resilience of the intestinal microbiota influences health and disease
| Autor: | Jeroen Raes, Felix Sommer, Richa Bharti, Jacqueline Moltzau Anderson, Philip Rosenstiel |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030106 microbiology Disease Biology digestive system Microbiology Inflammatory bowel disease 03 medical and health sciences Human health Microbial ecology medicine Homeostasis Humans Resilience (network) 2. Zero hunger General Immunology and Microbiology Metabolic disorder Fecal bacteriotherapy Fecal Microbiota Transplantation Inflammatory Bowel Diseases medicine.disease Gastrointestinal Microbiome 3. Good health Intestines 030104 developmental biology Infectious Diseases 13. Climate action Immunology Dysbiosis |
| Zdroj: | Nature Reviews Microbiology |
| ISSN: | 1740-1534 1740-1526 |
| Popis: | The resilience of the microbiota can protect us from disease, but a resilient dysbiotic microbiota may also cause disease. This Opinion article discusses the concepts and mechanisms of microbial resilience against dietary, antibiotic or bacteriotherapy-induced perturbations and the implications these have for human health. The composition of the intestinal microbiota varies among individuals and throughout development, and is dependent on host and environmental factors. However, although the microbiota is constantly exposed to environmental challenges, its composition and function in an individual are stable against perturbations, as microbial communities are resilient and resistant to change. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and also between the microorganisms and the intestinal interface of the host. The resilience of the healthy microbiota protects us from dysbiosis-related diseases, such as inflammatory bowel disease (IBD) or metabolic disorder. By contrast, a resilient dysbiotic microbiota may cause disease. In this Opinion article, we propose that microbial resilience has a key role in health and disease. We will discuss the concepts and mechanisms of microbial resilience against dietary, antibiotic or bacteriotherapy-induced perturbations and the implications for human health. |
| Databáze: | OpenAIRE |
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