Clonal analysis of sacrococcygeal 'teratomas'
| Autor: | K. L. Sinnock, Antonio R. Perez-Atayde, Kevin A. Boynton, George L. Mutter |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases Soft Tissue Neoplasms Clonal analysis Polymerase Chain Reaction X-inactivation Pathology and Forensic Medicine law.invention law medicine Humans Retroperitoneal Neoplasms Cloning Molecular neoplasms Polymerase chain reaction Retrospective Studies biology Sacrococcygeal Region Infant Newborn Teratoma medicine.disease female genital diseases and pregnancy complications Polyclonal antibodies Receptors Androgen Pediatrics Perinatology and Child Health Monoclonal biology.protein Immature teratoma Female |
| Zdroj: | Pediatric pathologylaboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association. 16(6) |
| ISSN: | 1077-1042 |
| Popis: | Congenital masses of the sacrococcygeal region commonly contain multiple tissues and have variously been subclassified as neoplasms or congenital hamartomas based on clinicopathological and embryological observations. We have used a polymerase chain reaction-based assay for nonrandom X chromosome inactivation to infer the clonality of three congenital sacrococcygeal tumors previously diagnosed as teratomas. One solid immature teratoma was monoclonal, and a predominantly cystic histologically mature mass was polyclonal. A third immature teratoma was noninformative because of baseline asymmetry of polyclonal tissue X inactivation. We confirm that immature teratomas at this site appear to be monoclonal neoplasms and suggest that at least some histologically mature “teratomas” are more appropriately classified as hamartomas. |
| Databáze: | OpenAIRE |
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