Tumor Oxygenation after 1) Carbogen and/or Perflubron Emulsion Administration in Tumor Xenografts 2) Carbogen Administration in Patients
| Autor: | M. Guichard, E. Lartigau, L. Martin, C. Thomas, P. Weeger, P. Lambin, A. M. Le Ridant, A. Lusinchi, P. Wibault, B. Luboinski, F. Eschwege |
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| Rok vydání: | 1994 |
| Předmět: |
Radiation-Sensitizing Agents
Partial Pressure Transplantation Heterologous Biomedical Engineering Mice Nude Mice chemistry.chemical_compound Carbogen Neoplasms Administration Inhalation Animals Distribution (pharmacology) In patient Fluorocarbons Inhalation Perflubron Oxygenation Carbon Dioxide Tumor Oxygenation Hydrocarbons Brominated Oxygen chemistry Anesthesia Drug Therapy Combination Emulsions Lymph Neoplasm Transplantation Biotechnology |
| Zdroj: | Artificial Cells, Blood Substitutes, and Biotechnology. 22:1355-1360 |
| ISSN: | 1532-4184 1073-1199 |
| DOI: | 10.3109/10731199409138837 |
| Popis: | This study examines the changes in tumor p02 distribution assessed by polarography (KIMOC 6650, Eppendorf) in 1) two human tumor xenografts after carbogen inhalation with or without a perflubron (perfluorooctylbromide) emulsion (OxygentTM, Alliance Pharmaceutical corp.) and in 2) human head and neck carcinomas after carbogen inhalation. Mice bearing HRT18 or NA11+ tumors were restrained and their body temperature was kept constant. Perflubron emulsion (4 ml/kg) was injected i.v. in the mice. In patients, oxygenation of the head and neck metastatic lymph nodes was assessed before and/or during carbogen exposure. The distribution of p02 values shifted upwards during carbogen exposure in both animals and patients while the proportion of low p02 values decreased. The maximal effect was obtained with patients after 1 to 6 minutes of carbogen exposure, but 4 patients still maintained very low ~02s. Carbogen plus 4 nil/kg perflubron emulsion was more efficient than carbogen alone for increasing hypoxic tumor p02 in animals. If the animals data could be extrapolated to humans, then the effect of carbogen on tumor oxygenation should be increased by perflubron emulsion administration. |
| Databáze: | OpenAIRE |
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