Specificity of effect of osmolality on aldosterone secretion
| Autor: | J. T. Glass, R. E. Taylor, K. J. Radke, E. G. Schneider |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Cortisol secretion medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Biology chemistry.chemical_compound Dogs Adrenocorticotropic Hormone Corticosterone Physiology (medical) Internal medicine Adrenal Glands medicine Animals Aldosterone Hydrocortisone Dose-Response Relationship Drug Adrenal gland Adrenal cortex Angiotensin II Osmolar Concentration Perfusion Kinetics medicine.anatomical_structure Endocrinology chemistry Zona glomerulosa Female sense organs medicine.drug |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 252:E118-E123 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | Small (3–7 mM) changes in [NaCl] have a marked inverse effect on angiotensin II- or K-stimulated aldosterone secretion by the isolated, perfused canine adrenal gland. The effect is due to the accompanying changes in osmolality rather than to the changes in [Na] or [Cl]. The present study was undertaken to determine whether osmolality is a specific and discrete signal that modulates the secretion of aldosterone only or is simply a nonspecific physical factor that alters the secretion of other adrenocortical hormones as well. The study also determined whether small changes in osmolality affect the conversion of corticosterone to aldosterone. The secretion of both cortisol and aldosterone by isolated canine adrenal glands responded in a dose-dependent fashion to adrenocorticotropin (ACTH), but in contrast to the rapid and potent modulating action of osmolality reported previously for angiotensin II- or K-stimulated aldosterone secretion, changes in osmolality at the midpoint of ACTH infusion had no detectable effect on either cortisol secretion or, unexpectedly, aldosterone secretion. This indicates that osmolality is a highly specific signal that modulates responsiveness of the zona glomerulosa to the factors, angiotensin II and K, which are considered to be most important in the acute regulation of aldosterone secretion, but does not influence secretion of cortisol by inner zones of the adrenal cortex. In glands treated with agents that block aldosterone production from endogenous precursors, small changes in osmolality had no detectable effect on the conversion of exogenous corticosterone to aldosterone.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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