Blood pressure increase detected by ambulatory monitoring correlates with hypoxemia reflecting sleep apnea severity
| Autor: | S. Gresova, Alexander Marossy, Viliam Donic, Martin Kundrik, Zoltan Tomori, Martin Kurpas, Adela Vrbenská |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
hypertension
hypoxemia Ambulatory blood pressure business.industry screening medicine.medical_treatment Sleep apnea Apnea General Medicine sleep apnea medicine.disease Hypoxemia blood pressure monitoring Mean blood pressure Blood pressure Anesthesia medicine Medicine Continuous positive airway pressure medicine.symptom business Hypopnea |
| Zdroj: | Open Medicine, Vol 4, Iss 2, Pp 222-232 (2009) |
| ISSN: | 2391-5463 |
| DOI: | 10.2478/s11536-009-0011-z |
| Popis: | Ambulatory blood pressure monitoring and parallel polysomnographic study were performed in 116 adult males divided into 6 groups. Thirty blood-pressure (BP) and polysomnographic variables were measured to test their usefulness for screening for both arterial hypertension and sleep apnea-hypopnea syndrome (SAHS). The development of severe breathing disorders and hypoxemia during sleep was attributed to SAHS, when compared with measurements in healthy controls and in patients with arterial hypertension. Such disorders manifested as an increased apnea-hypopnea index, apnea index, duration of arterial oxygen saturation of less than 85%, and decrease of average arterial oxygen saturation that correlated with nocturnal average diastolic BP (p=0.0049, p=0.0027, p=0.049 and p=0.0457, respectively). These respiratory disorders resulted in various nocturnal, rather than diurnal, and diastolic and systolic BP variables. The acute antihypertensive effect of continuous positive airway pressure therapy for SAHS significantly reduced the episodes of apnea and hypopnea and the secondary component of hypertension caused by excessive sympathetic stimulation. For the SAHS-induced, dose-dependent component of hypertension that responded to continuous positive airway pressure, the following variables, in decreasing significance, were useful: nocturnal average systolic and diastolic BP and 24-hour average systolic and diastolic BP, as well as percent time elevation and mean blood pressure load. The monitoring of these variables could contribute to early diagnostic and prognostic stratification of complications and adequate therapy of the secondary component of hypertension caused by SAHS. |
| Databáze: | OpenAIRE |
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