Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

Autor:	Anne T. Truesdale, Masato Nakano, Kendra E. Hightower, Yasushi Miyazaki, Eldridge N. Nartey, J. Darren Stuart, Laurie S. Kane-Carson, Hideyuki Sato
Rok vydání:	2007
Předmět:	Pyridines Stereochemistry VEGF receptors Receptor EphB4 Clinical Biochemistry Pharmaceutical Science Angiogenesis Inhibitors Thiophenes Binding Competitive Biochemistry Mice Structure-Activity Relationship chemistry.chemical_compound Adenosine Triphosphate Suzuki reaction Pyridine Drug Discovery Animals Furans Protein kinase A Protein Kinase Inhibitors Molecular Biology biology Chemistry Kinase Organic Chemistry 3T3 Cells General Medicine Receptor TIE-2 Vascular Endothelial Growth Factor Receptor-2 Combinatorial chemistry In vitro Atp competitive Template Drug Design biology.protein Molecular Medicine Pharmacophore
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:250-254
ISSN:	0960-894X
Popis:	A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973b7ffa3ec6a8505e5cc6077bea7d25 https://doi.org/10.1016/j.bmcl.2006.09.050 Zobrazit plný text záznamu Full Text from ScienceDirect