Prevalence of Toscana and Sicilian Phlebovirus Antibodies in Classic Kaposi Sarcoma Case Patients and Control Subjects in Sicily
| Autor: | Gianni Gori-Savellini, Maria Grazia Cusi, Melissa Valentini, Emanuele Amodio, Nino Romano, Rosalia Maria Valenti, James J. Goedert |
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| Přispěvatelé: | Amodio, E, Valentini, M, Gori-Savellini, G, Valenti, RM, Romano, N, Goedert, JJ, Cusi, MG |
| Rok vydání: | 2011 |
| Předmět: |
Male
Phlebovirus phlebovirus classic Kaposi sarcoma Sicily Comorbidity Biology Antibodies Viral Settore MED/42 - Igiene Generale E Applicata Immunoglobulin G Virus Major Articles and Brief Reports Seroepidemiologic Studies Humans Immunology and Allergy Seroprevalence Sarcoma Kaposi Aged Aged 80 and over Classic Kaposi Sarcoma Odds ratio Middle Aged biology.organism_classification Virology Infectious Diseases Immunoglobulin M Italy Herpesvirus 8 Human Immunology biology.protein Female Antibody |
| Zdroj: | The Journal of Infectious Diseases. 204:1423-1426 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jir546 |
| Popis: | To assess whether arthropod bites promote Kaposi sarcoma (KS), we determined the seroprevalence of Sicilian (SFSV) and Toscana (TOSV) phlebovirus antibodies in 30 patients with classic KS and 100 controls in Sicily. Nine (6.9%) subjects, all controls, were positive for SFSV, whereas 41 (31.5%) were positive for TOSV. Seroprevalence with immunoglobulin (Ig) M or IgG against either virus was significantly higher in controls (43% vs 13.3% in case patients; P < .01). Adjusted for age, IgG seroprevalence was significantly lower in KS patients compared to controls (adjusted odds ratio, 0.22; 95% confidence interval, .07–.72). Low phlebovirus seroprevalence in patients with KS may reflect incapacity to produce robust, persistent antibody responses, and suggests that arthropod bites do not promote KS. |
| Databáze: | OpenAIRE |
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