Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications
| Autor: | Kassibla Elodie Dempah, Christine M. Mahoney, Eric J. Munson, Matthew L. Becker, Cory Berkland, Supang Khondee, Jeffrey M. Davis, Mark Bailey |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Polymers and Plastics MRI contrast agent Organic Chemistry Radical polymerization Nanoparticle Nanotechnology Nuclear magnetic resonance spectroscopy Nanomaterials Secondary ion mass spectrometry chemistry.chemical_compound Monomer chemistry Polymer chemistry Materials Chemistry Copolymer |
| Zdroj: | Macromolecular Rapid Communications. 31:87-92 |
| ISSN: | 1521-3927 1022-1336 |
| DOI: | 10.1002/marc.200900505 |
| Popis: | Nanomaterials have emerged as valuable tools in biomedical imaging techniques. Here, the synthesis and characterization of a novel fluorinated nanoparticle with potential applications as an MRI contrast agent is reported. Particles were synthesized using a free radical polymerization technique. Secondary ion mass spectrometry analysis showed that the particles' surface contained fluorinated groups and nitrogen-containing groups. Solid-state NMR spectroscopy suggested the presence of two distinct fluorine resonances, which conforms to the structure of the fluorinated monomer. Ongoing studies aim to evaluate the performance of the nanoparticles as MRI contrast agents both in vitro and in vivo. |
| Databáze: | OpenAIRE |
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