Selective separation and inexpensive purification of paclitaxel based on molecularly imprinted polymers modified with ternary deep eutectic solvents
| Autor: | Zhuang-Fei Jiang, Jia-Yuan He, Zhining Xia, Chun-Su Yuan, Rong-Rong Ma, Ling Tan, Qi-Hui Zhang, Chong-Zhi Wang, Lian-Di Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Thermogravimetric analysis
Paclitaxel Clinical Biochemistry Pharmaceutical Science 01 natural sciences Analytical Chemistry Molecular Imprinting Adsorption Molecularly Imprinted Polymers Desorption Specific surface area Drug Discovery Spectroscopy Fourier Transform Infrared Fourier transform infrared spectroscopy Spectroscopy chemistry.chemical_classification 010405 organic chemistry Chemistry 010401 analytical chemistry Solid Phase Extraction Molecularly imprinted polymer Polymer 0104 chemical sciences Chemical engineering Selective adsorption Solvents |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 192 |
| ISSN: | 1873-264X |
| Popis: | Paclitaxel (PTX) is a powerful anticancer natural product, with its separation and purification having been widely studied. In this work, new molecular imprinted polymers (MIPs) using deep eutectic solvents (DESs) with different molar ratios were prepared as functional monomers. These were then used as adsorbents in solid phase extraction (SPE) for the separation of PTX from its structural analogs. The polymers were characterized by energy disperive X-rays (EDX), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FT-IR). The results suggested that the formative regular DES-MIPs had an even pore-size distribution and a large specific surface area. The dynamic adsorption and static adsorption showed that the DES-MIPs had excellent adsorption performance, with a maximum adsorption capacity and optimum adsorption time of 87.08 mg/g and 180 min, respectively. The selective adsorption experiments showed that the material had outstanding selectivity, and the maximum selectivity factor was 6.20. For stability, after six consecutive adsorption and desorption cycles, the DES-MIPs maintained the perfect stability and reusability. Furthermore, the fabricated SPE column was successfully utilized for extracting and eluting PTX. This study provides a reliable protocol for the separation and purification PTX from its structural analogs and the DES-MIPs materials have excellent potential application value in pharmaceutical industry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect