Distribution of Pseudorabies Virus Antigen in Hunting Dogs with Concurrent Paragonimus westermani Infection
| Autor: | Ryoji Yamaguchi, Uda Zahli Izzati, Chiho Kaneko, Takuya Hirai, Mathurot Suwanruengsri, Yasuyuki Kaneko, Ayako Yoshida, Tamaki Okabayashi |
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| Rok vydání: | 2021 |
| Předmět: |
Paragonimus westermani
Pathology medicine.medical_specialty Paragonimiasis viruses Pseudorabies Spleen Biology Pathology and Forensic Medicine Dogs Japan Working Dogs medicine Animals Dog Diseases Suid alphaherpesvirus 1 Antigens Viral General Veterinary Coinfection medicine.disease biology.organism_classification Herpesvirus 1 Suid Lymphatic system medicine.anatomical_structure Lymph Encephalitis |
| Zdroj: | Journal of Comparative Pathology. 188:44-51 |
| ISSN: | 0021-9975 |
| Popis: | Following isolation of pseudorabies virus (PRV) from two hunting dogs in Oita prefecture, Japan, we investigated the PRV antigen distribution in the tissues of the infected animals. At necropsy, PRV-associated lesions included facial oedema, tonsillar and meningeal congestion, blotchy haemorrhages on the pericardium and mitral valves, and incomplete splenic contraction in one dog, with less prominent findings in the other dog. Multiple pulmonary nodules were seen in both cases, caused by the diploid form of Paragonimus westermani lung flukes, as confirmed by PCR-restriction fragment length polymorphism and gene sequencing analyses. Histological examination revealed that the PRV infection was associated with lesions of non-suppurative encephalitis in the brainstem. PRV antigen was detected in the cerebrum, cerebellum, brainstem, submucosal and myenteric plexuses, and mononuclear cells, mainly in the bone marrow, lymph nodes, tonsils and spleen tissues. There was evidence of PRV dissemination to the brain via the trigeminal or olfactory routes, in addition to possible spread to lymphoid organs via infected mononuclear cells. |
| Databáze: | OpenAIRE |
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