Smoking Associated with Reduced Odds of Sjögren’s Syndrome among Rheumatoid Arthritis Patients
| Autor: | Robert T. Greenlee, Maria Schletzbaum, J J VanWormer, Christie M. Bartels, S S McCoy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Adolescent Immunology MEDLINE Article Odds Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Prospective Studies Autoantibodies 030203 arthritis & rheumatology Review study business.industry Medical record Smoking General Medicine medicine.disease Cross-Sectional Studies Sjogren's Syndrome Rheumatoid arthritis Female Sjogren s business |
| Zdroj: | Scand J Rheumatol |
| Popis: | OBJECTIVE: The objective of this medical record review study is to define the association between smoking and Sjӧgren’s syndrome (SS) in a large RA cohort. METHODS: Electronic health records from a population-based cohort were screened for RA eligibility between 2005– 2018. Inclusion criteria were age ≥ 18 years, two or more RA diagnoses, including two diagnoses by a rheumatologist or a positive rheumatoid factor or anti-CCP antibody. The independent variable, smoking status, was defined as never, current, or past. The outcome, SS, was defined by two or more ICD-9 codes. Multivariable logistic regression was performed to determine odds ratios (ORs) of SS adjusted for age, sex, and race. RESULTS: Among 1,861 patients with RA identified for cohort inclusion, 1,296 patients had a reported smoking status. Current smokers were younger and were less likely female than never and past smokers. Adjusted OR of current compared to never smokers was negatively associated with SS (OR 0.20 [95% Confidence Interval (CI) 0.06-0.65]). Female sex and age were associated with SS (OR 2.70 [95% CI 1.18-6.14]; OR 3.75 [95% CI 1.23-11.4]). CONCLUSIONS: We report that RA patients who currently smoke had 80% lower odds of SS. We found age had a 3.7 fold association and female sex a 2.7 fold association with SS among RA patients. Our data suggest a negative correlation between current smoking and prevalent SS among RA patients. Prospective studies examining pack-year relationships or cessation impacts could further examine risk reduction and causality to follow-up our cross-sectional observational study. |
| Databáze: | OpenAIRE |
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