A case of breast cancer metastatic to the tail of the pancreas
| Autor: | Hajime Tanaka, Kazuo Narushima, Noriyuki Tohnosu, Toshitaka Uehara, Takashi Maruyama, Takanori Shimizu, Yoshiji Watanabe, Taku Kato, Takeshi Saito, Keita Sunouchi, Satoru Ishii, Shinichiro Shimizu |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Lobular carcinoma Bone Neoplasms Breast Neoplasms Risk Assessment Metastasis Neoplasms Multiple Primary Mastectomy Modified Radical Breast cancer Surgical oncology medicine Carcinoma Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging skin and connective tissue diseases Radical mastectomy Neoplasm Staging business.industry Biopsy Needle Carcinoma Ductal Breast General Medicine Middle Aged medicine.disease Combined Modality Therapy Immunohistochemistry Pancreatic Neoplasms Treatment Outcome medicine.anatomical_structure Oncology Chemotherapy Adjuvant Female business Pancreas Mastectomy Follow-Up Studies |
| Zdroj: | Breast Cancer. 13:225-229 |
| ISSN: | 1880-4233 1340-6868 |
| Popis: | Breast cancer metastasis to pancreas is rarely seen. There have been only 6 cases described in the literature. We present the seventh case of a 54-year-old woman with breast cancer that metastasized to the tail of the pancreas 4 years and 4 months after radical mastectomy. Although the serum levels of CA15-3 and TPA had gradually increased without symptoms, it was difficult to establish the diagnosis before contrast-enhanced abdominal CT scan was performed. Immunohistochemical staining using E-cadherin was positive, proving that the breast cancer was ductal rather than lobular in origin. CA15-3 immunohistochemically stained positive in the resected pancreas lesion. Positive monoclonal staining by GCDFP-15 (gross cystic disease fluid protein-15) in the pancreas tumor also confirmed it breast cancer origin. Investigation of chemokine/chemokine receptors may clarify a new mechanism of metastasis to the pancreas from breast cancer. |
| Databáze: | OpenAIRE |
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