Priming of measles virus-specific humoral- and cellular-immune responses in macaques by DNA vaccination
Autor: | Helma W. Vos, Albert D. M. E. Osterhaus, Koert J. Stittelaar, Rik L. de Swart, T. Fabian Wild, Geert van Amerongen, Nathalie Sixt |
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Přispěvatelé: | Virology |
Rok vydání: | 2002 |
Předmět: |
Paramyxoviridae
Measles Vaccine Antibodies Viral Measles DNA vaccination Measles virus Interferon-gamma SDG 3 - Good Health and Well-being Morbillivirus Vaccines DNA medicine Animals Mononegavirales General Veterinary General Immunology and Microbiology biology Vaccination Public Health Environmental and Occupational Health biology.organism_classification medicine.disease Virology Macaca fascicularis Infectious Diseases Immunoglobulin M Immunoglobulin G Immunology Molecular Medicine Measles vaccine |
Zdroj: | Vaccine, 20. Elsevier |
ISSN: | 0264-410X |
Popis: | Although the currently used live attenuated measles vaccines are safe and effective, they are dependent on cold chain maintenance and are often ineffective in young infants due to interference by maternal antibody. Therefore, besides vector-based vaccines, different new generation non-replicating candidate measles vaccines are being considered, including nucleic acid vaccines. We have vaccinated cynomolgus macaques transdermally with DNA plasmids encoding measles virus (MV) proteins. Following two vaccinations, low serum antibody responses were detected. Wild-type measles virus challenge 1 year after vaccination showed reduced viraemia in some animals. However, accelerated humoral- and cellular-immune responses were observed in all vaccinated macaques, demonstrating successful priming by the DNA vaccines. |
Databáze: | OpenAIRE |
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