The clinical pathology of Crimean-Congo hemorrhagic fever
| Autor: | S. Harvey, P. A. Leman, D. E. Gill, R. Swanepoel, A. J. Shepherd, J. H. Mynhardt |
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| Rok vydání: | 1989 |
| Předmět: |
Microbiology (medical)
Crimean–Congo hemorrhagic fever myalgia Male medicine.medical_specialty Gastroenterology Tanzania South Africa Internal medicine medicine Animals Humans Blood coagulation test Disseminated intravascular coagulation Cross Infection medicine.diagnostic_test business.industry Platelet Count Congo-Crimean Hemorrhagic Fever Petechial rash medicine.disease Namibia Infectious Diseases Immunology Democratic Republic of the Congo Female Hemorrhagic Fever Crimean Blood Coagulation Tests medicine.symptom business Crimean Congo hemorrhagic fever virus Blood Chemical Analysis Partial thromboplastin time |
| Zdroj: | Reviews of infectious diseases. 11 |
| ISSN: | 0162-0886 |
| Popis: | Observations were made of 15 fatal and 35 nonfatal Crimean-Congo hemorrhagic fever (CCHF) infections diagnosed from February 1981 to March 1987 in Kimberly and Sandringham, Republic of South Africa. Following an incubation period of 2-9 days after exposure to infection, patients had a sudden onset of disease with fever, nausea, severe headache, and myalgia. Petechial rash and hemorrhagic signs such as epistaxis, hematemesis, and melena supervened on days 3-6 of illness. Deaths occurred on days 5-14 of illness. Patients with fatal infections had thrombocytopenia and markedly elevated levels of serum aspartate and alanine aminotransaminases, gamma-glutamyltransferase, lactic dehydrogenase, creatine kinase, bilirubin, creatinine, and urea. Total protein, albumin, fibrinogen, and hemoglobin levels were depressed. Values for prothrombin ratio, activated partial thromboplastin time, thrombin time, and fibrin degradation products were grossly elevated, findings that indicate the occurrence of disseminated intravascular coagulopathy. Many of the clinical pathologic changes were evident at an early stage of the disease and had a highly predictive value for fatal outcome of infection. Changes were present but less marked in nonfatal infections. |
| Databáze: | OpenAIRE |
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