AIDS-associated intraocular lymphoma causing primary retinal vasculitis
| Autor: | J E Puklin, L D Ormerod |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Vasculitis Pathology medicine.medical_specialty Eye Diseases Population chemistry.chemical_compound Retinal Diseases Vitrectomy Biopsy Humans Immunology and Allergy Medicine education Lymphoma AIDS-Related education.field_of_study medicine.diagnostic_test Brain Neoplasms business.industry Retinal vasculitis Eye Neoplasms Brain biopsy Retinal Vessels Retinal medicine.disease Magnetic Resonance Imaging Lymphoma Vitreous Body Ophthalmology chemistry B-Cell Non-Hodgkin Lymphoma Intraocular lymphoma business |
| Zdroj: | Ocular Immunology and Inflammation. 5:271-278 |
| ISSN: | 1744-5078 0927-3948 |
| DOI: | 10.3109/09273949709085068 |
| Popis: | There is an increasing association between ocular-central nervous system (CNS) lymphoma and the acquired immunodeficiency syndrome (AIDS). In this population, the disease generally occurs in a younger age group. The origin of these B-cell neoplasms remains unknown.Case study of a 26-year-old AIDS patient with an incidental finding of localized retinal vasculitis and local vitritis. Disease progression and the failure of antiviral therapy led to early diagnostic vitrectomy with vitreal and retinal biopsy. Cerebrospinal fluid (CSF) evaluation, head magnetic resonance imaging (MRI), and brain biopsy were performed.The diagnosis of ocular non-Hodgkin lymphoma was made by vitreous cytology. Serial sectioning of a retinal biopsy showed no retinal neoplastic infiltration, only perivascular inflammatory cells. CSF was normal. MRI showed multicentric brain mass lesions that enhanced with intravenous contrast. Brain biopsy revealed an immunoblastic, angiocentric, B-cell non-Hodgkin lymphoma. The patient died within two months, despite cerebral and ocular irradiation.The segmentally localized retinal vasculitis-vitritis and absence of retinal infiltration suggested early primary involvement of the vitreous. Coarse perivascular sheathing is characteristic of the mixed retinal vasculitis in this disease. The diagnosis of ocular-CNS lymphoma must be considered in patients with AIDS, however young, with unexplained posterior segment inflammatory disease or subretinal masses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|