The effects of 3,3′,4,4′-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum
| Autor: | Mary A. Stuart, Craig J. McClain, Farrel R. Robinson, Jack Schmidt, Tim Borges, Kadhim N. Salman, Larry W. Robertson, Miao Li |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Polybrominated Biphenyls chemistry.chemical_element Feed conversion ratio Hazardous Substances Article Rats Sprague-Dawley Animal science Weight loss Internal medicine medicine Animals Environmental Chemistry Molybdenum biology Copper toxicity Ceruloplasmin Organ Size General Medicine Metabolism medicine.disease Pollution Copper Diet Rats Endocrinology chemistry Dietary Supplements biology.protein medicine.symptom Injections Intraperitoneal Corn oil |
| Zdroj: | Environmental Science and Pollution Research. 21:6400-6409 |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | Copper (Cu) metabolism is altered in rats fed diets high in molybdenum (Mo) and low in Cu. This 10-week study was carried out to examine the effects of supplemental Mo (7.5–240 μg/g diet) on male Sprague Dawley rats fed diets adequate in Cu (5 μg/g diet); and to determine the susceptibility of Mo-treated animals to the environmental pollutant 3,3′,4,4′-tetrabromobiphenyl (TBB). After seven weeks of dietary treatment, half the rats in each group received a single IP injection of TBB (150 μM/Kg bw), while the other half received the corn oil vehicle. Rats sacrificed at 10 weeks showed no effects of Mo on growth, feed efficiency, or selected organ or tissue weights. Dose-dependent effects on plasma Mo (0 – 5.1 μg/mL), Cu (0.95 – 0.20 μg/mL) and bone Cu (3.4 – 10 μg/g), in control through the high-dose were found. Cu sequestration in bone of Mo-treated rats is a new finding. TBB treatment resulted in dramatic weight loss and loss of absolute organ mass. Relative organ weights were increased, except for the thymus. TBB altered amino acid concentrations of certain amino acids. Compared to control rats, this polybrominated biphenyl congener significantly decreased plasma Cu and ceruloplasmin at higher concentrations of dietary Mo, and promoted the process of plasma Cu decrease by Mo, suggesting a combined effect. |
| Databáze: | OpenAIRE |
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