The gold-standard genome of Aspergillus niger NRRL 3 enables a detailed view of the diversity of sugar catabolism in fungi
| Autor: | Aguilar-Pontes, M V, Brandl, J, McDonnell, E, Strasser, K, Nguyen, T T M, Riley, R, Mondo, S, Salamov, A, Nybo, J L, Vesth, T C, Grigoriev, I V, Andersen, M R, Tsang, A, de Vries, R P, Sub Software Technology begr. 1-1-13, Sub Cell Biology, Sub Molecular Plant Physiology, Celbiologie, Molecular Plant Physiology |
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| Přispěvatelé: | Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Fungal Physiology, Sub Software Technology begr. 1-1-13, Sub Cell Biology, Sub Molecular Plant Physiology, Celbiologie, Molecular Plant Physiology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030106 microbiology Mycology & Parasitology Computational biology Microbiology Genome 03 medical and health sciences Gold standard genome Genetics Sugar lcsh:QH301-705.5 Sugar catabolism Gene Aspergillus biology Genomic diversity Catabolism Classical genetics Human Genome Aspergillus niger biology.organism_classification Agricultural and Biological Sciences (miscellaneous) 030104 developmental biology lcsh:Biology (General) Adaptation |
| Zdroj: | Studies in Mycology, 91, 61-78. Westerdijk Fungal Biodiversity Institute Studies in Mycology, 91, 61. Centraalbureau voor Schimmelculturen Studies in mycology, vol 91, iss 91 Aguilar-Pontes, M V, Brandl, J, McDonnell, E, Strasser, K, Nguyen, T T M, Riley, R, Mondo, S, Salamov, A, Nybo, J L, Vesth, T C, Grigoriev, I V, Andersen, M R, Tsang, A & de Vries, R P 2018, ' The gold-standard genome of Aspergillus niger NRRL 3 enables a detailed view of the diversity of sugar catabolism in fungi ', Studies in Mycology, vol. 91, pp. 61-78 . https://doi.org/10.1016/j.simyco.2018.10.001 Studies in Mycology, Vol 91, Iss, Pp 61-78 (2018) Studies in mycology, vol 91, iss 1 |
| ISSN: | 0166-0616 |
| DOI: | 10.1016/j.simyco.2018.10.001 |
| Popis: | The fungal kingdom is too large to be discovered exclusively by classical genetics. The access to omics data opens a new opportunity to study the diversity within the fungal kingdom and how adaptation to new environments shapes fungal metabolism. Genomes are the foundation of modern science but their quality is crucial when analysing omics data. In this study, we demonstrate how one gold-standard genome can improve functional prediction across closely related species to be able to identify key enzymes, reactions and pathways with the focus on primary carbon metabolism.Based on this approach we identified alternative genes encoding various steps of the different sugar catabolic pathways, and as such provided leads for functional studies into this topic. We also revealed significant diversity with respect to genome content, although this did not always correlate to the ability of the species to use the corresponding sugar as a carbon source. Key words: Aspergillus, Genomic diversity, Gold standard genome, Sugar catabolism |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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