Corrigendum to 'Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway' [The Veterinary Journal 196 (2013) 414–423]
| Autor: | Ted R. Hupp, Helen Sang, David Argyle, Thalia Blacking, Roderick Else, Lisa Y. Pang, Adrian Sherman, Bruce Whitelaw |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
DNA damage
Adenosine Deaminase Antineoplastic Agents Mammary Neoplasms Animal Ataxia Telangiectasia Mutated Proteins Biology Cat Diseases Feline Mammary Carcinoma Mice Agammaglobulinemia Antigens CD Radioresistance Animals AC133 Antigen Glycoproteins General Veterinary Carcinoma Neoplasms Experimental Gene Expression Regulation Neoplastic Drug Resistance Neoplasm Cancer research Cats Neoplastic Stem Cells Animal Science and Zoology Female Severe Combined Immunodeficiency Stem cell Tumor Suppressor Protein p53 Corrigendum Peptides DNA Damage |
| Zdroj: | Veterinary Journal (London, England : 1997) |
| ISSN: | 1532-2971 1090-0233 |
| Popis: | Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial-mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats. |
| Databáze: | OpenAIRE |
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