Association Between Microbial Bioburden and Healing Outcomes in Venous Leg Ulcers: A Review of the Evidence
| Autor: | Marie S. Tuttle |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Advances in Wound Care. 4:1-11 |
| ISSN: | 2162-1934 2162-1918 |
| DOI: | 10.1089/wound.2014.0535 |
| Popis: | Significance: Venous leg ulcers (VLUs) are susceptible to microbial invasion, and serious complications can result without the timely control of infection. Diagnosis of wound infection is primarily based on subjective clinical characteristics and patient-reported symptoms, and the treatment with antimicrobials has not consistently shown improvement in healing outcomes. This is a review of studies using bacterial cultures and/or new molecular-based methods associating microbial bioburden with healing outcomes in VLU patients, with the goal of guiding future studies to better determine significant patterns of microbial involvement in chronic wounds. Recent Advances: Studies reviewed here use cultivation-based identification of bacteria and next-generation sequencing of the bacterial 16S rRNA gene to gain insight into microbial bioburden in VLUs. Further application of sophisticated DNA sequencing and bioinformatic analyses has the potential to revolutionize our ability to further discern, with high resoluti... |
| Databáze: | OpenAIRE |
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