Oncogene-induced senescence: a potential breakpoint mechanism against malignant transformation in plasma cell disorders

Autor:	Jing Xu, Jens Hillengass, Hartmut Goldschmidt, Jonas Leichsenring, Albrecht Stenzinger, Nicola Lehners, Elena Ellert, Mindaugas Andrulis, Marc S. Raab
Rok vydání:	2018
Předmět:	Adult Cyclin-Dependent Kinase Inhibitor p21 Male Smoldering Multiple Myeloma 0301 basic medicine Senescence Cancer Research Plasma Cells Plasma cell Monoclonal Gammopathy of Undetermined Significance Malignant transformation 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins medicine Humans Cellular Senescence Multiple myeloma Aged Aged 80 and over Mechanism (biology) Chemistry Breakpoint Hematology Middle Aged medicine.disease Immunohistochemistry Cell Transformation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology Hematological malignancy 030220 oncology & carcinogenesis Cancer research Oncogene-induced senescence Female Multiple Myeloma Cyclin-Dependent Kinase Inhibitor p27
Zdroj:	Leukemia & Lymphoma. 59:2660-2669
ISSN:	1029-2403 1042-8194
Popis:	Oncogene-induced senescence (OIS) is a cellular tumor-suppressive mechanism present in several premalignant conditions. Here, we analyze the possible impact of OIS on malignant transformation in plasma cell disorders. Tumor samples from 125 patients with different disease stages were analyzed immunohistochemically for expression of senescence markers. Protein expression of cyclin-dependent kinase inhibitor p21
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972976d8731c6acd65a6fe25e8cce071 https://doi.org/10.1080/10428194.2018.1443450 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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