sPECAM-1 and sVCAM-1: role in pathogenesis and diagnosis of chronic hepatitis C and association with response to antiviral therapy
| Autor: | Adam Ziółkowski, Agnieszka Berdowska, Ewa Janczewska-Kazek, Krystyna Zwirska-Korczala, Marek Waluga, Elzbieta Wozniak-Grygiel, Blazej Nowak, Michał Kukla, Andrzej Gabriel, Andrzej Wiczkowski, Mariusz Kalinowski, Barbara Rybus-Kalinowska |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
business.industry
Ribavirin Gastroenterology Antiviral therapy Fibrosis stage Review medicine.disease Pathogenesis chemistry.chemical_compound chemistry Chronic hepatitis Fibrosis Immunology Medicine lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 business Cell adhesion Soluble Vascular Cell Adhesion Molecule 1 |
| Zdroj: | Therapeutic Advances in Gastroenterology, Vol 2 (2009) |
| Popis: | Aim: To analyze the relationship between pretreatment clinical or histological features and the levels of soluble platelet-endothelial cell adhesion molecule-1 (sPECAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), to determine their serum concentration in responders and nonresponders, to evaluate the behavior under antiviral therapy, to explain their relationship in response to therapy and to assess the association between these two molecules in chronic hepatitis C (CHC). Methods: The study analyzed 65 CHC patients, including 50 patients (Group 1) with marked fibrosis treated with peginterferon plus ribavirin, 15 patients without fibrosis (Group 2) and 13 healthy volunteers (the control group, Group 3). sPECAM-1 and sVCAM-1 levels were assessed by an immunoenzymatic method (ELISA) before and after therapy. Results: sVCAM-1 and sPECAM-1 serum concentrations increased significantly in CHC patients (p Conclusions: Hepatitis C virus (HCV) infection results in upregulation of sPECAM-1 and sVCAM-1. sPECAM-1 levels are related to necroinflammatory activity and may also identify patients with advanced fibrosis. The sPECAM-1 value was decreased by therapy but its measurement cannot predict therapy outcome and confirm HCV persistence. sPECAM-1 may influence VCAM-1 expression. |
| Databáze: | OpenAIRE |
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