HLA-A AND HLA-B ALLELES ASSOCIATED IN PSORIASIS PATIENTS FROM MUMBAI, WESTERN INDIA

Autor:	Kanjaksha Ghosh, Shankarkumar Umapathy, Deepak Khuperkar, U Khopkar, JP Devaraj, R Mitra, Aruna Pawar
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	business.industry Western India Dermatology Human leukocyte antigen Odds ratio psoriasis lcsh:RL1-803 medicine.disease HLA-B Mumbai HLA-A Serology Basic Research Psoriasis Immunology medicine lcsh:Dermatology HLA antigens Allele business Allele frequency
Zdroj:	Indian Journal of Dermatology Indian Journal of Dermatology, Vol 56, Iss 5, Pp 497-500 (2011)
ISSN:	1998-3611 0019-5154
Popis:	Background: Psoriasis, a common autoimmune disorder characterized by T cell-mediated keratinocyte hyperproliferation, is known to be associated with the presence of certain specific Human Leukocyte Antigen (HLA) alleles. Aim: To evaluate distribution of HLA-A and HLA-B alleles and hence identify the susceptible allele of psoriasis from patients in Western India. Materials and Methods: The study design included 84 psoriasis patients and 291 normal individuals as controls from same geographical region. HLA-A and HLA-B typing was done using Serology typing. Standard statistical analysis was followed to identify the odds ratio (OR), allele frequencies, and significant P value using Graphpad software. Results: The study revealed significant increase in frequencies of HLA-A2 (OR-3.976, P
Databáze:	OpenAIRE
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