Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project

Autor: Mary H. Ward, Malaquías López-Cervantes, Eva Negri, Shoichiro Tsugane, Bárbara Peleteiro, Claudio Pelucchi, Domenico Palli, Areti Lagiou, Lizbeth López-Carrillo, Rossella Bonzi, Akihisa Hidaka, Nuno Lunet, Stefania Boccia, Samantha Morais, Reza Malekzadeh, Lina Mu, Niclas Håkansson, Maria Constanza Camargo, Paola Bertuccio, Guo Pei Yu, David Zaridze, Kenneth C. Johnson, Jinfu Hu, Eva María Navarrete-Muñoz, Pagona Lagiou, Ana Rute Costa, Monica Ferraroni, Robert C. Kurtz, Juan Alguacil, Carlo La Vecchia, Gerson Shigueaki Hamada, Ana Ferro, Alicja Wolk, Maria Paula Curado, Raúl U. Hernández-Ramírez, Zuo-Feng Zhang, Jesús Vioque, Paolo Boffetta, Roberto Persiani, Gemma Castaño-Vinyals, Matteo Rota, Farhad Pourfarzi, Dmitry Maximovich, Mohammadreza Pakseresht
Přispěvatelé: Instituto de Saúde Pública da Universidade do Porto, A. Ferro, A. R. Costa, S. Morai, P. Bertuccio, M. Rota, C. Pelucchi, J. Hu, K. C. Johnson, Z. -F. Zhang, D. Palli, M. Ferraroni, G. -P. Yu, R. Bonzi, B. Peleteiro, L. Lopez-Carrillo, S. Tsugane, G. S. Hamada, A. Hidaka, R. Malekzadeh, D. Zaridze, D. Maximovich, J. Vioque, E. M. Navarrete-Munoz, J. Alguacil, G. Castano-Vinyal, A. Wolk, N. Hakansson, R. U. Hernandez-Ramirez, M. Pakseresht, M. H. Ward, F. Pourfarzi, L. Mu, M. Lopez-Cervante, R. Persiani, R. C. Kurtz, A. Lagiou, P. Lagiou, P. Boffetta, S. Boccia, E. Negri, M. C. Camargo, M. P. Curado, C. La Vecchia, N. Lunet
Rok vydání: 2020
Předmět:
Zdroj: International journal of cancer, vol 147, iss 11
INTERNATIONAL JOURNAL OF CANCER
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
Int J Cancer
Arias Montano. Repositorio Institucional de la Universidad de Huelva
ISSN: 1097-0215
0020-7136
Popis: A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.
The authors thank the European Cancer Prevention (ECP) Organiza- tion for providing support for the project meetings. Our study is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant), the Italian Ministry of Health (Young Researchers, GR-2011-02347943 to SB) and the Italian League for the Fight against Cancer (LILT). This project was also supported by FEDER through the Operational Programme Competi- tiveness and Internationalization and national funding from the Foun- dation for Science and Technology - FCT (Portuguese Ministry of Science, Technology and Higher Education) under the Unidade de Investigaç ~ ao em Epidemiologia - Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (UIDB/04750/2020). AF (PD/BD/ 105823/2014) was awarded with an individual scholarship through national funding from FCT/MCTES. Individual grants attributed to ARC (SFRH/BD/102181/2014) and BP (SFRH/BPD/108751/2015) were funded by the FCT and the “ Programa Operacional Capital Humano ” (POCH/FSE). SM was funded under the project “ NEON-PC - Neuro-oncological complications of prostate cancer: longitudinal study of cognitive decline “ (POCI-01-0145-FEDER-032358; Ref. PTDC/SAU-EPI/32358/2017). We also thank all MCC-Spain study collaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva, University of Oviedo, University of Cantabria, University of León, Granada, Instituto Salud Pública de Navarra, FISABIO, Murcia Regional Health Authority and collaborators). The funding source had no role in the study design; collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
Databáze: OpenAIRE
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