Fruit juice consumption modulates antioxidative status, immune status and DNA damage
| Autor: | H. Müller, Achim Bub, Bernhard Watzl, Mark Blockhaus, Gerhard Rechkemmer, Karlis Briviba, Beatrice L. Pool-Zobel, Ute M. Liegibel |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Antioxidant DNA damage Polymers Endocrinology Diabetes and Metabolism Lymphocyte medicine.medical_treatment Clinical Biochemistry Cyanidin Biological Availability Epigallocatechin gallate Biology Lymphocyte Activation Biochemistry Antioxidants Beverages chemistry.chemical_compound Immune system Phenols Malondialdehyde medicine Humans Food science Molecular Biology Flavonoids Nutrition and Dietetics Cross-Over Studies Immunity food and beverages Polyphenols Carotenoids medicine.anatomical_structure chemistry Polyphenol Fruit Interleukin-2 Oxidation-Reduction Biomarkers DNA Damage |
| Zdroj: | The Journal of nutritional biochemistry. 14(2) |
| ISSN: | 0955-2863 |
| Popis: | Polyphenolic compounds exert a variety of physiological effects in vitro including antioxidative, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men on a low-polyphenol diet, we determined the effects of 2 polyphenol-rich juices (330 ml/d) supplemented for 2 weeks on bioavailability of polyphenols, markers of antioxidative and immune status, and reduction of DNA damage. Juices provided 236 mg (A) and 226 mg (B) polyphenols with cyanidin glycosides (A) and epigallocatechin gallate (B) as major polyphenolic ingredients. There was no accumulation of plasma polyphenols after two weeks of juice supplementation. In contrast, plasma malondialdehyde decreased with time during juice interventions. Moreover, juice consumption also increased lymphocyte proliferative responsiveness, with no difference between the two juices. Interleukin-2 secretion by activated lymphocytes and the lytic activity of natural killer cells were significantly increased by both juices. Juice intervention had no effect on single DNA strand breaks, but significantly reduced oxidative DNA damage in lymphocytes. A time-delay was observed between the intake of fruit juice and the reduction of oxidative DNA damage and the increase in interleukin-2 secretion. We conclude that consumption of either juice enhanced antioxidant status, reduced oxidative DNA damage and stimulated immune cell functions. However, fruit juice consumption for 2 weeks did not result in elevated plasma polyphenols in subjects after overnight fasting. Further studies should focus on the time-delay between juice intake and changes in measured physiological functions, as well as on active polyphenolic metabolites mediating the observed effects. |
| Databáze: | OpenAIRE |
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