Optical Characterization of Ciprofloxacin Photolytic Degradation by UV-Pulsed Laser Radiation

Autor: Mihai Boni, Angela Staicu, Mihail Lucian Pascu, Tatiana Tozar
Rok vydání: 2021
Předmět:
laser degradation
absorption spectroscopy
Materials science
Absorption spectroscopy
Ultraviolet Rays
Pharmaceutical Science
02 engineering and technology
010501 environmental sciences
01 natural sciences
Article
Analytical Chemistry
law.invention
QD241-441
ciprofloxacin
law
Spectroscopy
Fourier Transform Infrared
Drug Discovery
Irradiation
Physical and Theoretical Chemistry
Fourier transform infrared spectroscopy
Photodegradation
Absorption (electromagnetic radiation)
0105 earth and related environmental sciences
Photolysis
Organic Chemistry
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
021001 nanoscience & nanotechnology
Laser
Fluorescence
HPTLC densitometry
FTIR
Chemistry (miscellaneous)
Molecular Medicine
Water treatment
fluorescence
0210 nano-technology
Nuclear chemistry
Zdroj: Molecules
Molecules, Vol 26, Iss 2324, p 2324 (2021)
Volume 26
Issue 8
ISSN: 1420-3049
DOI: 10.3390/molecules26082324
Popis: Ciprofloxacin is one of the most prescribed antibiotics in treating bacterial infections, becoming an important pollutant of the wastewaters. Moreover, ciprofloxacin is hard to be destroyed by conventional water treatment processes
therefore, efficient treatments to destroy it are needed in water decontamination. This study offers insights into the performance of 266 nm laser beams on the photodegradation of ciprofloxacin. An Nd:YAG laser was used that emitted 266 nm at an energy of 6.5 mJ (power of 65 mW) and ciprofloxacin water solutions were irradiated up to 240 min. The irradiated solutions were investigated by UV-Vis and FTIR absorption spectroscopy, pH assay, and laser-induced fluorescence. An HPTLC densitometer was used to characterize the laser-induced fluorescence and fluorescence lifetime of photodegradation products. The UV-Vis absorption, FTIR, and laser-induced fluorescence spectra showed the degradation of ciprofloxacin. Moreover, HPTLC densitometry offered the fluorescence and fluorescence lifetime of ciprofloxacin and its three photoproducts as well as their relative quantification. From the FTIR spectra, the molecular structure of two out of three photoproducts was proposed. In conclusion, the laser irradiation method provided the efficient photodegradation of ciprofloxacin, whereas the analytical techniques offered the proper means to monitor the process and detect the obtained photoproducts.
Databáze: OpenAIRE
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