Hypermethylated Genes of MicroRNA in Ovarian Carcinoma: Metastasis Prediction Marker Systems
| Autor: | D. O. Utkin, Eleonora A. Braga, M. V. Fridman, Tatiana P. Kazubskaya, A M Burdennyi, D. S. Khodyrev, I. V. Pronina, N. E. Kushlinskii, E. A. Filippova, Vitaly I. Loginov, D. N. Kushlinskii |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biology Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine Ovarian carcinoma microRNA medicine Humans Gene Ovarian Neoplasms General Medicine Methylation DNA Methylation medicine.disease Predictive value Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology DNA methylation Cancer research Female Ovarian cancer 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 167:79-83 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04465-5 |
| Popis: | We identified a group of miRNA genes whose methylation is associated with ovarian cancer metastasis. Based on these data, new markers and the systems of markers predicting tumor dissemination were selected. Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR-129-2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. The greatest association was established for 4 genes: MIR-137, MIR-193a, MIR-34b/c, and MIR-130b (p |
| Databáze: | OpenAIRE |
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