Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure
| Autor: | Višnja Karačić, K Trutin-Ostović, Marija Zavalić, Rajka Turk, Ana Bogadi-Šare |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
0301 basic medicine
Blood Cell Count with Differential Adult Glycerol medicine.medical_specialty Erythrocytes benzene hematologic effects occupational exposure red blood cell glycerol lysis time Health Toxicology and Mutagenesis Mean corpuscular hemoglobin 010501 environmental sciences Hematocrit Toxicology 01 natural sciences 03 medical and health sciences Internal medicine Occupational Exposure medicine Humans Mean corpuscular volume 0105 earth and related environmental sciences Hematologic Tests 030102 biochemistry & molecular biology Mean corpuscular hemoglobin concentration medicine.diagnostic_test Red Cell Chemistry Public Health Environmental and Occupational Health Benzene Middle Aged Red blood cell Endocrinology medicine.anatomical_structure Biochemistry Case-Control Studies Female Hemoglobin Toluene |
| Zdroj: | Toxicology and industrial health. 13(4) |
| ISSN: | 0748-2337 |
| Popis: | Forty-nine female workers in the shoemaking industry, exposed to a solvent mixture containing benzene and twenty-seven non-exposed controls, were investigated. Concentrations of benzene and toluene in the working atmosphere, as well as benzene and toluene in blood and phenols in pre- and post-shift urine as parameters of biological monitoring, were determined. In order to assess hematotoxic risk, a complete blood cell count with differential, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, reticulocytes, serum iron, alkaline phosphatase in neutrophils and red blood cell glycerol lysis time were determined in all subjects. Benzene concentrations in the workplace atmosphere at the shoemaking factory ranged from 1.9 to 14.8 ppm (median=5.9). Significant difference in benzene in blood (p = 0.005) and phenol in post-shift urine (p = 0.003) between exposed workers and controls confirmed exposure to benzene. Hemoglobin level (p = 0.02) and mean corpuscular hemoglobin concentration (p = 0.0002) in the shoe workers were lower, and band neutrophils (p = 0.005) and mean corpuscular volume (p = 0.03) higher, than in controls. Red blood cell glycerol lysis time was significantly higher (p = 0.000001) in shoe workers (X ± SD = 41.6 ± 8.9) than in controls (X ± SD = 31.1 ± 6.5) and showed a significant correlation with exposure biomarkers. The results confirm that benzene exposure below 15 ppm may produce qualitative abnormalities, particularly macroerythrocytosis and increased red cell glycerol resistance, in the absence of an overt quantitative decrease in circulating blood cells. Increased resistance to the hemolytic action of glycerol is a potentially useful biological monitoring procedure in medical surveillance of benzene exposed workers. The results of this study suggest that potential threshold concentration for hematologic effects of benzene is lower than 15 ppm. |
| Databáze: | OpenAIRE |
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